The American Visionary Art Museum is full of "Folk Art" produced by self-taught individuals, usually without formal training. The Inner Harbor campus features three historic renovated industrial buildings, sculpture gardens, a museum store and restaurant.

For some cultural entertainment, add Fort Myers's Art Walks and Music Walks to your agenda: these free happenings animate the social scene of the downtown River District at fixed times every month, while shops, art galleries and restaurants stay open until late at night, providing drinks on the sidewalk. The Art Walk takes place every first Friday of the month, 6pm–10pm, and takes you to 13 art galleries that offer self-guided tours and meet-ups with the artists. The Music Walk starts every third Friday of the month at 7pm, with bands and singers taking over the streets, performing in a wide range of music genres.

Zisa Palace is a 12th century castle built for King William I of Sicily. Its name derives from the Arabic word "al-Aziz", which means splendid. The original Norman building underwent some changes during the years, especially with the decorations added during the Baroque period. The Islamic inspiration for the architecture is clearly visible in the decorations of the vestibule, where Arabic vaults and columns are interposed by Baroque frescoes and marble decorations. Today, the castle houses a museum of Islamic art.

For an excursion, head over to the amazing castle of Lorca. To get up to the castle, take the small road train that directly leaves at the visitor centre called Lorca centre. You will meet costumed performers who will re-enact everyday life in the castle.