For some cultural entertainment, add Fort Myers' Art Walks and Music Walks to your agenda: these free happenings animate the social scene of the downtown River District at fixed times every month, while shops, art galleries and restaurants stay open until late at night, providing drinks on the sidewalk. The Art Walk takes place every first Friday of the month, 6pm–10pm, and takes you to 13 art galleries that offer self-guided tours and meet-ups with the artists. The Music Walk starts every third Friday of the month at 7pm, with bands and singers taking over the streets, performing in a wide range of music genres.

The narrow alleyways of the Jewish quarter contain homes of many ancient Hebrew families. Here, while tourists take pictures, Jewish teenagers head to their Yeshivas, schools for Torah studies. Near the Cardo you will find the Hurva Synagogue: recently restored, it offers beautiful views over the roofs of the quarter. Built by Ashkenazi Jews in the 16th century, the synagogue has been destroyed and banned several times; for Jewish people it's a symbol of their tormented history.

The Metropolitan Cathedral of São Paulo or simply Catedral da Sé is an imposing neo-gothic church located in Praça da Sé. It is 46 meters wide, 111 meters long, and has a dome 65 meters high. It was one of the first churches built in São Paulo–its first construction started in 1591–and today it is considered one of the largest neo-gothic temples in the world. It contains a crypt with the remains of Cacique Tibiriçá, the first Indian converted and baptized by the Jesuits José de Anchieta and Leonardo Nunes. It is also worth noting its grandiose organ–the largest in Latin America.