Düsseldorf's Altstadt (Old Town) is also home to some of the city's most beautiful churches. For instance, the Sankt Lambertus Basilika, which was first built in the 13th century, and which with its twisting spire helps make Düsseldorf's skyline unique. In conjunction with the Schlossturm (Castle Tower) and the River Düssel, the basilica remains part of the Old Town's original core. This church's parish altar also houses a shrine containing relics of Saint Apollinaris, the city's patron saint.

The Rheinturm (built 1979 – 1982, architect H. Deilmann) is a striking landmark on the Düsseldorf’s Rhine skyline. It stands on the edge of the southern city centre, at the entrance to the MedienHafen, right beside the North Rhine-Westphalian parliament building (Landtag) and the building of the public broadcaster, Westdeutscher Rundfunk. It is 240.5 metres high, with a glass-fronted 180-seat restaurant at an altitude of 172.5 metres that rotates on its axis. A bar and lounge is located below the restaurant (168m) as is a viewing platform (164m) with a breathtaking view of the Rhine metropolis: the MedienHafen, the Altstadt, the Hofgarten, Königsallee and the Rhine with its family of bridges all lie at the feet of the tower. When the weather is good, one can see as far as Cologne Cathedral. Thanks to a level entrance in the basement of the tower, the building offers barrier-free access.

Built between 1906 and 1912, Casa Milà, commonly known as La Pedrera ('The stone quarry'), is a modernist building in Passeig de Gràcia and the last private residence designed by Catalan architect Antoni Gaudí. Its interior is even more striking than its wrought-iron, stone-carved facade, especially the rooms displaying where people actually lived. So get inside Casa Milà to discover another one of Gaudí's unconventional architectural creations.