Located in the heart of the city, this museum of fine arts provides visitors with a unique opportunity to stroll through the historic surroundings of an Augustinian monastery and marvel at its impressive collection of sculptures and paintings from the Middle Ages to the early 20th century.

With over 5,000 animals on display and in their care, the South Carolina Aquarium is sure to delight all ages. Highlights include the Hurricane Simulator, which recreates the sensation of being in a hurricane, and the immersive 4-D theater.

For some cultural entertainment, add Fort Myers' Art Walks and Music Walks to your agenda: these free happenings animate the social scene of the downtown River District at fixed times every month, while shops, art galleries and restaurants stay open until late at night, providing drinks on the sidewalk. The Art Walk takes place every first Friday of the month, 6pm–10pm, and takes you to 13 art galleries that offer self-guided tours and meet-ups with the artists. The Music Walk starts every third Friday of the month at 7pm, with bands and singers taking over the streets, performing in a wide range of music genres.

As the site of the first shots fired during the Civil War, Fort Sumter has a strong place in American History. On a boat ride to Fort Sumter, hear about events that led to the War between the states. After an hour touring Fort Sumter, the boat returns back to either of the two departure locations.