This architecturally striking church, named after Saint Thérèse of Lisieux, known as the 'Little Flower', provides visitors with a glimpse into the Syro-Malabar rite, one of the oldest Eastern Catholic traditions. The church's murals and intricate stained glass windows depict scenes from the life of St Thérèse. Visitors can also appreciate the unique blend of Indian and Western architectural styles, reflecting the region's diverse cultural influences.

The Museum of Fine Arts of Bilbao is one of Spain's most important art institutions. Its origins trace back to the first Fine Arts Museum, founded in 1908, and the Museum of Modern Art opened in 1924. These two museums merged in 1945, forming the current institution. The museum's extensive collection spans from the 12th century to contemporary art, featuring masterpieces by renowned artists such as El Greco, Goya, Velázquez, Picasso, and Francis Bacon. Notably, it houses the most significant collection of Basque art, including works by Regoyos, Zuloaga, and Echevarría.

Built from the late 14th to the 15th centuries, the Santiago Cathedral is the city’s oldest major church, dedicated to Saint James (Santiago), Bilbao's patron saint. The building features a mix of different styles: its core is Gothic (nave, vault, cloister), a grand Renaissance portico was added in the 1500s, while much of the façade and tower with spire were rebuilt in a neo-Gothic style in the late 1800s by Severino de Achúcarro. Inside, you’ll see three naves, several side chapels, the Gothic cloister accessible via the Door of the Angel ('Puerta del Ángel'), and beyond the main altar, there’s an ambulatory with chapels. Floods in 1983 caused damage, but the cathedral was restored and reopened around 2000.