The most interesting aspect of this museum is the building itself - a mosque with the only intact minaret in the Aegean Islands. The museum contains a clutter of Hellenistic statuary, Roman slabs and a collection of Turkish, Jewish and Armenian tombstones that hint at the island’s multi-ethnic past.

Teatro Villamarta is a cultural hub and the city's main scene for theatre, music, and dance shows, hosting also yearly festivals. Exceptional performances can be seen weekly, ranging from flamenco dance to musicals.

Declared by Unesco as “World Heritage Site”, the town of Portobelo is known as a “historic monument collection” since you can visit several sites in the same place. Many of the fortresses, castles and buildings have been preserved almost intact along the years: examples are Fort Santiago, San Jeronimo, San Fernando, the Customs and Controller’s building, and the San Juan de Dios Church famous for the Black Christ. During the sixteenth and seventeenth century, Portobelo became one of the most important silver-exporter ports of Nueva Grenada, the Spanish Colonial Jurisdiction which included today's Colombia, Panama, Ecuador and Venezuela. Portobelo also became one of the most important departure points from the “Indies”. For the same reason, this town was subject to many pirate attacks from Francis Drake, William Parker, William Hiking, Henry Morgan, Edward Vernon, and William Kingles. This coastal town is famous for serving excellent seafood and it is close to other great Caribbean destinations.

"New Monastery" is a misnomer – this imposing religious institution was founded in the 11th century by the Byzantine Emperor Constanine IX Monomachos. It is, perhaps, the finest religious building in the Aegean islands, with mosaics that date back to the golden age of Byzantine religious art.