Hortus Botanicus is one of the world's oldest botanical gardens established in 1638 as an herb garden with medicinal plants for Amsterdam doctors and pharmacists. The plants were brought here from all over the world by the traders of the Dutch East India Company (VOC). Today, Hortus Botanicus holds more than 6,000 different plants, including unique ones, like the 2,000 years old agave cactus and a 300-year-old Eastern Cape giant cycad. The garden's orangery has a beautiful cafe with a large outside terrace open to the garden. Find some peace and quiet here, especially on a drizzly day.

The Moselle Valley wine region spans France, Luxembourg, and Germany, with wineries closest to Luxembourg City located within less than a half-hour's drive from there. The scenic river valley offers abundant wine-tasting opportunities for Riesling and Elbling aficionados; tastings can be arranged at most local wineries, but contacting in advance to check for availability is recommended. If in doubt, try Caves du Sud in Remerschen, Caves St Martin or Caves Desom Saint-Remy in Remich, or Domaine Mathes and Domaine Alice Hartmann in Wormeldange. The region is also excellent hiking grounds, with hiking trails and cycling paths, with boat tours running along the Moselle.

Luxembourg's 'Little Switzerland' is defined by splendid landscapes and unusual rock formations, which can be explored on foot via the Mullerthal Hiking Trail, spanning a total of 112 kilometres. The regional capital is Echternach, the oldest city in Luxembourg, which is worth a visit for its historic Benedictine abbey, Roman Villa remains, and fantastic local produce.